Cable later asked Domino to help train X-Force and she joined the team as co-leader. On the eve of Earth being overlapped with Reality-295 during the Age of Apocalypse, Domino and Cable confessed their true feelings and kissed. After reality was restored, Domino helped Cable restructure X-Force before investigating a series of murders committed by a feral Grizzly, who forced her to kill him. Domino agreed to share a psionic link with Cable as a sign of their mutual trust. Later, Domino and Cable received a call for help from former Six Pack teammate Garrison Kane and discovered him with Copycat. The emotion-manipulating Psycho-Man made Domino attack Copycat, whom she already resented for her role in her year-long captivity, after which he kidnapped the mutant shapeshifter to the Microverse. Domino, Cable, and Kane teamed with the Micronauts to oppose the villain.
Domino soon learned Milo Thurman was alive when Donald Pierce and his cyborg Reavers captured him to gain his alleged prophetic abilities through cybernetic conversion. Domino was forced to kill Thurman to defeat Pierce's plans. Domino was then asked by G.W. Bridge to help prevent S.H.I.E.L.D. agent Danielle Moonstar from being exposed by the government’s Operation: Zero Tolerance. Moonstar was undercover acting as a member of the Mutant Liberation Front (MLF) who had taken control of a medical research center they believed was engaged in anti-mutant research. Posing as a camera crew, Domino, Sunspot (Roberto Da Costa), and Siryn infiltrated the facility, unaware that Zero Tolerance forces had discerned their true identities. After being assaulted by Prime Sentinels, Domino was captured by their commander, Ekatarina Gryaznova, and a neural inhibitor was planted at the base of her skull that created a synaptical static which caused her reflex and reaction times to become increasingly erratic. Seeking to overcome the device’s effects and reclaim her fighting prowess, Domino left X-Force, broke up with Cable, and returned to her mercenary ways.
She was later contacted by mutant Jesse Aaronson, who sought her help in finding his brother. In exchange, Aaronson offered to reveal Gryaznova’s whereabouts and took Domino to the Aguilar Institute in California where she was captured by her old foe, now calling herself Gryphon. Aaronson turned to X-Force for help rescuing his ally and then used his technology disrupting power to deactivate Domino’s implant, after which she defeated Gryaznova.
Subsequently rejoining X-Force, Domino quit when Pete Wisdom offered to turn the team into a proactive black ops unit. She was later possessed by the Undying alien Aentaeros who sought to use her to kill its rival Semijan. However, Cable intervened and forced Aentaeros to release Domino. She drifted back into freelance work and took an assignment that marked her as a target of mutant assassin Marcus Tsung, who killed her. She was soon revived by alien technology grafts, then turned to X-Force for help in defeating Tsung. Wisdom’s sister Romany had the alien tech removed from Domino to create a techno-organic world engine, then sent British mutant Corben to kill X-Force. But he failed, and the team confronted their tormentor. The engine was destroyed in an explosion that seemingly killed all of X-Force except Domino, though the others soon resurfaced.