Not much is known about Jane's history prior to meeting Thor. She was a nurse for Dr. Don Blake and over time developed feelings for him. She was torn between "the lame Doctor" and the heroic Thor. Unknown to her at the time, Blake and Thor were the same person. This situation continued until Thor could bear it no more. Defying Odin's orders, he broke down and revealed his secret identity to Ms. Foster and proceeded to transport her to Asgard. There, Jane was briefly granted immortality and the power of the Gods. She was unable to cope with her new powers and asked to be put back on Earth as she once was. Odin, upset at her unworthiness to be a goddess, agreed and whisked her back to Midgard. Back on Earth, with amnesia forced onto her by Odin, she met her husband Dr. Keith Kincaid and had a son with him. Years passed and one day Jane became extremely ill on the verge of death. Sif came to her rescue by infusing her own life force with Jane's as she lay on her deathbed. By doing so Jane recovered her lost memories and her love for Thor was revived.
During the Civil War event, Jane took Captain America's side against the registration act, and joined his resistance group.
