They encouraged Danny Rand to continue on his journey to K'un-Lun, regain his powers from longtime enemy Davos, and save the city. This once again rekindled Misty and Danny's on-again, off-again relationship.
Heroes for Hire later came back thanks to Namor's Oracle company and original Human Torch, Jim Hammond. When the group ran into trouble, Hammond called in Misty and Colleen to help on a mission to Symkaria alongside Power Man and Iron Fist. Later, Danny Rand nearly died but Brother Voodoo used soul parts of Misty, Colleen, Luke and Heroes for Hire member White Tiger to bring him back to life.
The Daughters of the Dragon continued their jobs as private investigators and bondswomen. They took on Rhino, Whirlwind, and a new player by the name of Ricadonna. Along the way, they made friends with a pair of villains named Orka and Humbug who would reappear on their next endeavor.
After the Stamford tragedy, Misty and Colleen met with Iron Man, Mr. Fantastic, and Spider-Man to discuss the Heroes for Hire working directly for the government to bring in unregistered super humans. They agreed, but only to bring in villains, not their friends. This decision did not sit well with longtime comrades Luke Cage and Danny Rand.
Even though they stood on opposite sides of the Civil War, Misty, Colleen and Luke agreed to help Jeryn Hogarth, who was blackmailed into helping a man named Xao destroy K'un-Lun. Xao used his Hydra agents to kidnap Hogarth's mother. To ensure her safety, he helped Xao build a magnetic train that would be filled with explosives and driven through a portal into the mystical city. While Iron Fist dealt with a variety of factors on his end, the three New York City-based heroes fought Hydra forces to stop Xao's plan and save Mrs. Hogarth.
Misty and Colleen returned to their government-backed Heroes for Hire squad which included Black Cat, Paladin, Shang-Chi, Orka, Humbug, and Tarantula, though not everyone on that team proved a team player, or even a full-on hero. After surviving the Savage Land, the team ultimately fell apart during World War Hulk, especially after Misty traded their safety for that of fellow member Moon Boy. This caused Colleen to split from her longtime partner.
With the Heroes for Hire in ruins, Misty had time to rekindle her relationship with Danny Rand. They moved in together around the same time that Rand focused on selling off his company and using the money to set up dojos and other programs to help people. Together they fought off some foes, but were both excited to find that Misty was pregnant. Unfortunately, this proved a false positive, something that sometimes happens to Immortal Weapons. After discovering the truth, the pair drifted apart.
Always ready to help a friend, Misty accompanied Cage, Iron First, Shang-Chi, and Colleen in an attempt to talk to Daredevil after he build Shadowland on top of a block that Bullseye had destroyed in Hell's Kitchen. After fighting off Murdock's Hand ninja--he had been taken over at that point and was possessed by a demon--Misty went back to work. While looking into a Shadowland-related case, she found herself teaming up with Paladin, Silver Sable, and the Shroud to figure out who had been framing the Hand for murder.
That experience partially led to Knight reforming the Heroes for Hire, this time with a new set-up. She used her many connections in the mask community to deliver in-ear communicators to various individuals and call on them when their skills were needed. Misty acted as Control, calling the shots from a home base. In reality, she had been in a coma for months as the Puppet Master pulled her strings for Zebediah Killgrave, also known as the Purple Man.
Knight and Paladin worked to regain whatever reputation they had as Heroes for Hire before they found out about Puppet Master. They eventually succeeded and helped out during Spider-Island, then Misty made a gutsy play to start Villains for Hire. Instead of officially making a heel turn, Misty worked out a plan with Paladin to make her seem worse than she was so she could not only get the criminals she worked with locked up but also draw Purple Man out and end his reign of terror. After working with Paladin so closely, the two began a brief romantic relationship.
Misty and Danny attempted to rekindle their relationship not long after, but were interrupted when a nearly dead Fat Cobra appeared on Iron Fist's doorstep telling him someone was killing the Immortal Weapons. When Misty asked what Danny had been up to with his Defenders teammates, he couldn't tell her because of their interactions with the Concordance Engine. Since she thought he was keeping things from her, she hit the pause button on their relationship.
In the wake of Fear Itself, Misty teamed up with another incredible female fighter, the Asgardian Valkyrie. They focused on restarting the Valyrior with eight women warriors from Earth and put together a group that consisted of Dr. Annabelle Riggs, Dani Moonstar, Hippolyta, and many of Misty's Heroes for Hire contacts to fend off the Doom Maidens. After that battle, which resulted in Annabelle's death, Valkyrie decided that the Valyrior didn't need to be restarted, so Misty walked away with her friends.
Misty rejoined after Valkyrie and Clea brought Annabelle back from Valhalla, but with them sharing a body. Reunited, the new Defenders dealt with threats like the Ghost Boys' Brood farm in the sewers under New York City and Caroline LeFay's mission to gain more power. The group survived Thanos' Wardogs, the Doom Maidens, and an attack on New Amazonia before Misty tapped Frankie Raye to stop LeFay's obvious plan without knowing she'd also been working to bring her mother Morgan LeFay back to life.
Just after finishing up with the Defenders, Knight and Wing reunited to help their friend Shang-Chi even though it ruined their stakeout. The Daughters of the Dragon stuck around to back Shang's mission, but then went their own ways again.
Knight later popped up in the Super Villain-run country of Bagalia where she had been deep undercover for S.H.I.E.L.D. until Sam Wilson came crashing into the country soon after becoming Captain America. After saving Cap from Crossbones, the two worked hand-in-hand to stop Baron Zemo's plans of spreading a vampire-born contagion around the planet. At the end of that adventure, Misty pulled Sam out of the water after an explosive battle with Baron Blood.
After Secret Wars, Knight kept working with Wilson in his crusade as a different kind of Captain America. Along the way they dealt with bigots and rioters as much as big events like Avengers: Standoff and Civil War II.
Even though she and Wilson kept very busy, Misty still had time to help out her old friends Power Man and Iron Fist as well as Black Panther. To save the latter from Ezekiel Stane, she joined the Crew alongside Luke Cage, Storm, and Manifold. Back in Harlem, Misty found herself working alongside these same heroes to figure out who murdered activist Ezra Miller.